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Does Niacin Work to Pass A Drug Test? Meda Pharmaceuticals - Niacin (vitamin b3) is promoted for rapidly clearing the body of drugs of abuse, such as cocaine and cannabis, and is alleged to interfere with urine drug screening. People who take niacin pills to help them pass a urine drug test may not only fail the test, but also land themselves in the emergency room, according to doctors. It works. You should also read this: Ccs Test Prep