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Zoloft Uses, Side Effects, Dosages, Precautions - Zoloft (sertraline) is not tested on a standard drug screening panel. Doxylamine, found in unisom and other over the counter sleep aids (similar to diphenhydramine), may cause a false positive on a drug test for methadone, opiates, and. Before taking a real drug test, it’s a good idea to test yourself at home. It may also cause a. Will zoloft. You should also read this: Tabe Test Practice Math