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Lamotrigine (Lamictal) Reclaim Joy Medical - If you provide a urine sample for drug screening, tell the laboratory staff. Lamictal may produce a false positive result during a drug screening test. Can lamotrigine make you fail a drug test? Will lamictal show up on a urine test? If you are required to take a drug test, inform the testers that you are taking lamictal. You should also read this: Will Lunesta Show On A Drug Test