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What Not to Eat Before a Drug Test? Recovery Ranger - Cold medications, antihistamines, and other otc drugs are likely to interfere with urine drug screens. If you receive a false positive test, ask your healthcare provider to run a second test that’s more specific. Taking nyquil in the recommended dosage is beneficial in curing your cold. Cold medicine can initially affect drug tests, but typically won't cause a confirmed positive. You should also read this: Emissions Testing Newington Ct

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